Synthesis and characterization of oxygen bridged complexes of metal chelates of isonitrosopropiophenone with alkali and alkaline earth metal salts and study of their biological activitiy

In the present study we have synthesized new binuclear complexes of alkali and alkaline earth metal salts with interaction of stable metal chelates of isonitrosopropiophenone of Ni(II) & Cu(II) having general formula [Ma(INPP)2.MbL] and [Ma(INPP)2.MbX] for alkali metal adducts and [ Ma(INPP)2.MbL2] and [ Ma(INPP)2.MbX2] for alkaline earth metal adducts where Ma=Ni (II) or Cu(II) and Mb =Li+ , Na+ k+ , Mg++ or Ca++ , L=deprotonated 1-nitroso-2-naphthol and 8-hydroxyquinoline, X= ClO4 , SCN_ or Cl_ . The IR spectral studies suggests that the Ni(II) & Cu(II) metal chelats act as ligand and coordination towards alkali metal and alkaline earth metal salts takes place through oxygen atom of oximino group. The diffuse reflectance electronic spectra and magnetic moment values of the metal chelates and binuclear complexes with alkali and alkaline earth metal salts indicates the change in geometry during oxygen bridge complex formation. The lower molar conductivities values indicates the covalent nature of the adducts. Some of the complex compounds have shown significant biological activity against the Asperquillus nidulans.